Chelsea are set to be without Gary Cahill for the Wembley showdown.
The England defender has captained the Blues this term but has been treated for gastroenteritis and is set to miss out against Tottenham.
Nathan Ake is expected to replace Cahill rather than departing skipper John Terry.
Goalkeeper Thibaut Courtois has recovered from an ankle problem while Marcos Alonso is also likely to return.
Tottenham remain without Danny Rose fore the encounter against Chelsea.
The England left-back is back in training after a knee injury but will not be involved.
Michel Vorm is also out for Mauricio Pochettino’s men meaning No.1 Hugo Lloris will make a rare appearance in the competition.
Provisional Chelsea squad : Courtois, Begovic, Fabregas, Zouma, Alonso, Kante, Hazard, Loftus-Cheek, Moses, Pedro, Costa, Matic, Willian, Batshuayi, Terry, Azpilicueta, Chalobah, Luiz, Eduardo, Aina, Ake.
Provisional Tottenham squad: Lloris, Lopez, Whiteman, Davies, Alderweireld, Vertonghen, Dier, Wimmer, Walker, Trippier, Wanyama, Dembele, Eriksen, Alli, Sissoko, Onomah, Son, Janssen, Kane.
Antonio Conte admits he is battling doubts and injuries ahead of Chelsea’s FA Cup semi-final showdown with Spurs today conceding: We are up against it.
The Blues boss said: “This is a situation very clear for us – we are in trouble. But we are ready.”
Gary Cahill is out of the Wembley clash with gastroenteritis. Rookie Nathan Ake is set to replace him ahead of John Terry, who could now be denied a Wembley farewell ahead of his summer exit.
Diego Costa is without a goal since early March. Thibaut Courtois is recovering from an ankle injury and Conte – who claimed not to know who his captain will be today – will have to pick a team with Tuesday’s tough League home game against Southampton in mind.
The Italian, whose title advantage is down to just four points, added: “It’s not a simple situation now for us, because you have to consider that you have to play a semi-final in a great competition.
“Then, after two and a half days you have to play against Southampton, and Southampton have rested for 10 days.”